JINGKE YANG
Cary
Summary
Accomplished Senior Medical Director at Parexel International with expertise in global Phase I–III trial leadership and risk assessment. Proven track record in cell and gene therapy strategy, mentoring teams, and achieving zero critical audit findings. Adept at client engagement and driving innovative research, with over 30 peer-reviewed publications.
Overview
12
12
years of professional experience
Work History
SENIOR MEDICAL DIRECTOR
Parexel International
Cary
10.2021 - Current
- Lead physician for 15+ ongoing Phase I–III trials in AML, MDS, lymphomas, myeloma, prostate, lung, and breast cancers; programs enroll >1,200 patients across North America, EU, and APAC.
- Chair global medical monitoring meetings; analyze safety signals and implement mitigation strategies—zero critical audit findings to date.
- Provide medical and scientific leadership in proposals and bid defenses.
- Medical and Strategy Lead in the Cell & Gene Therapy section; mentored eight medical directors
ASSOCIATE CHIEF PHYSICIAN, HEMATOLOGY‑ONCOLOGY
The Affiliated Cancer Hospital of Zhengzhou University
Zhengzhou
01.2015 - 12.2017
- Managed 700–800 inpatients annually and performed >50 hematopoietic stem‑cell transplants.
- Principal/Co‑Investigator in multiple registration trials, including the pivotal Phase II zanubrutinib study leading to FDA approval.
- Led multidisciplinary care and published 30+ peer‑reviewed papers; awarded two patents.
RESEARCH FELLOW, Wellman Center for Photomedicine
Massachusetts General Hospital / Harvard Medical School
Boston
08.2013 - 01.2015
- Discovered photobiomodulation therapy to enhance hematopoietic stem‑cell engraftment and treat immune thrombocytopenia; findings published in Scientific Reports.
Education
Ph.D. - Hematology
Xiangya Medical School, Central South University
Changsha, China01.2010
MS - Pharmacology
Medical School of Zhengzhou University
Zhengzhou, China01.2007
M.D. -
Medical School of Zhengzhou University
Zhengzhou, China01.2004
Skills
- Medical Monitoring & Safety Oversight
- Cell & Gene Therapy Strategy & Execution
- Hematology & Oncology Clinical Practice
- Global Phase I–III Trial Leadership
- Risk Assessment & Benefit–Risk Management
- ICH‑GCP, FDA, EMA, NMPA Compliance
- Cross‑functional Team Leadership & Training
- Client Engagement & Bid Defense
Affiliations
- American Society of Hematology (ASH)
- American Association for Cancer Research (AACR)
Earlier Career
- Hematology‑Oncology Fellowship, Zhengzhou University, 01/01/10, 12/31/13
- Resident Physician, Second Xiangya Hospital, Central South University, 01/01/07, 12/31/09
Board Certification
Hematology‑Oncology, China, 2015
Selected Publications
- Zeng Z, Yang J, et al. Signal Transduct Target Ther 2024;9:229.
- Yang J, Wang L, Wu M. Sci Reports 2020;10:19671.
- Zhang Q, Steensma D, Yang J, et al. Leukemia 2019;33:217–229.
Languages
- English, fluent
- Mandarin Chinese, native
Core Expertise
- Medical Monitoring & Safety Oversight
- Cell & Gene Therapy Strategy & Execution
- Hematology & Oncology Clinical Practice
- Global Phase I–III Trial Leadership
- Risk Assessment & Benefit–Risk Management
- ICH‑GCP, FDA, EMA, NMPA Compliance
- Cross‑functional Team Leadership & Training
- Client Engagement & Bid Defense
Personal Information
Citizenship: U.S. Citizen
Timeline
SENIOR MEDICAL DIRECTOR
Parexel International
10.2021 - Current
ASSOCIATE CHIEF PHYSICIAN, HEMATOLOGY‑ONCOLOGY
The Affiliated Cancer Hospital of Zhengzhou University
01.2015 - 12.2017
RESEARCH FELLOW, Wellman Center for Photomedicine
Massachusetts General Hospital / Harvard Medical School
08.2013 - 01.2015
Ph.D. - Hematology
Xiangya Medical School, Central South University
MS - Pharmacology
Medical School of Zhengzhou University
M.D. -
Medical School of Zhengzhou University
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